What are Restylane, Perlane, Juvederm and Juvederm ultra plus?
These are cosmetic dermal fillers made of Hyluranic acids that replace lost volume and restore youthful contours to the skin, to smooth away moderate to severe facial wrinkles and folds, such as the lines from your nose to the corners of your mouth (nasolabial folds).
What are Hyluranic Acids (HAs)?
These are clear colorless gels, synthetic, most of them are not animal obtained products. HAs are natural substance found in many tissues throughout the body and present in particularly high amount in the skin and joint tissue and the fluid that fills the joints. In the human body natural hyaluronic acid acts as a lubricants for the joints and it provides volume and fullness to the skin.
Who provides HAs, are they FDA approved?
Many different manufactures are providing hyluranic acids (HAs) with similar formulas and features. These are approved by the FDA for the treatment of moderate to severe facial wrinkles and folds, like the ones from your nose to the corners of your mouth.
Following HAs are approved as a dermal fillers
- Restylane and perlane provided by Medicis , FDA approved 2003.
- Juvederm abd Juvederm ultra plus provided by Allergan, FDA approved 200.
- Hylafom marketed by Inemed, FDA approved April of 2004.
- Captique marketed by Inamed corporation, FDA approved Dec. 2004.
Following HAs are approved for medical proposes
- Hyalgan is a leading HA injected into the joints(knee) as a lubricant a treatment for osteoarthritis.
- Synvisc is another popular injectable joint lubricant.
- and more products what are beyond the scope of this website.
How long do Hyluranic acids products last?
Restylane® products are proven to deliver long-lasting results. Restylane lasts about six months. Perlane® lasts at least six months, in a majority of patients. The products’ patented stabilization technology helps maintain the cosmetic effect for those time periods.
What is the history of Restylane®
Restylane® has been used in over 1.4 million treatments in the U.S. and is available in more than 70 countries. It is the most-studied cosmetic dermal filler in the world with dozens of publications in medical literature. Clinical studies showed no significant differences in the safety of Restylane® and Perlane®.
What should patients do prior to treatment?
Restylane® and Perlane® require no pretesting, but you should take a few precautions before being treated. Avoid using aspirin, non-steroidal anti-inflammatory medications, St. John’s Wort, or high doses of Vitamin E supplements prior to treatment, because these may increase bruising or bleeding at the injection site. Also, if you have previously suffered from facial cold sores, inform Dr. Shafa about it. If needed free medication will be provided to prevent fever blister breakout after our injectable.
Do hyluranic acids require an allergy testing prior to injection?
No. HAs do not require an allergy test and can be administered immediately – no waiting is required.
How are Hyluranic acids type fillers administered?
These are administered by injection through a very fine needle to the treatment site, just like BOTOX®.
Is any of the material left in the skin after it has dissolved?
No. Over time Hyluranic acids products are broken down and eliminated by the body – unlike permanent fillers.
Do the injections hurt?
Restylane® products are injected directly into the skin in small amounts by an ultra-fine needle. As with all injections, some patients may experience discomfort. To increase your comfort, Dr. Shafa will assess your need for pain management and determine what technique is right for you.
How much do treatments cost?
A Restylane® or Perlane® procedure is customized to your specific needs, so the cost will vary. In general, the cost is comparable to the cost of similar procedures.
How often should I schedule an appointment?
How long the aesthetic correction lasts is very individual. Dr. Shafa will talk to you about the benefits of scheduling a follow-up appointment in about six months.
How are Restylane® products different than other hyaluronic acid-based products?
Restylane® and Perlane® contain no animal proteins. This limits any risk of animal-based disease transmission or allergic reaction. You should not use these products if you have allergies to microorganisms known as gram-positive bacteria.
Which dermal filler is the market leader?
Restylane® is the number one selling dermal filler in the U.S. and worldwide.
How do Hyluranic acids such as Restylane and Juvederm differ from Botox® Cosemetic?
Botox® and HAs are used to correct wrinkles in different ways. Restylane and Juvederm products are natural, cosmetic fillers injected into the skin, adding volume to smooth wrinkles such as the lines from your nose to the corners of your mouth (nasolabial folds). In contrast, Botox® relaxes the muscles that cause frown lines between your eye brows.
What is the different between Restylane and Juvederm?
Restylane was the first cosmetic dermal filler made from hyaluronic acid that has been modified slightly to last longer than the body’s hyaluronic acid.
How do I choose between Restylane, Perlane®?
You don’t have to. In clinical trials, Restylane® and Perlane® were used in the same patients. The hyaluronic acid in both products is made by the same biotechnical process. The difference is in the gel particle size. Perlane gel particles are larger and designed for deeper injection than Restylane. Dr. Shafa will decide which product is right for you based on an evaluation of facial wrinkles and folds.





